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General: Transient elevations of BUN (blood urea nitrogen) and serum creatinine have been observed, at recommended doses, the nephrotoxic potential of ceftriaxone is the same as other cephalosporins.
Dosage adjustments are not necessary in patients with hepatic dysfunction; however in patients with both renal failure and hepatic dysfunction, dosage should not exceed more than 2 g daily with close monitoring of serum concentrations.
Use in Children: Ceftriaxone sodium + Sulbactam sodium (Cefsul IV) 1 g/500 mg powder for injection (I.M./I.V.) should not be administered to hyperbilirubinemic neonates, especially premature.
